Alex Franzusoff Selected Research

Neoplasms (Cancer)

5/2016	Poxvirus-based active immunotherapy synergizes with CTLA-4 blockade to increase survival in a murine tumor model by improving the magnitude and quality of cytotoxic T cells.
1/2016	Poxvirus-Based Active Immunotherapy with PD-1 and LAG-3 Dual Immune Checkpoint Inhibition Overcomes Compensatory Immune Regulation, Yielding Complete Tumor Regression in Mice.
1/2014	Elucidating immunologic mechanisms of PROSTVAC cancer immunotherapy.
8/2010	Mutation-specific control of BCR-ABL T315I positive leukemia with a recombinant yeast-based therapeutic vaccine in a murine model.
3/2010	Concurrent vaccination with two distinct vaccine platforms targeting the same antigen generates phenotypically and functionally distinct T-cell populations.
2/2009	Human dendritic cell maturation and activation by a heat-killed recombinant yeast (Saccharomyces cerevisiae) vector encoding carcinoembryonic antigen.
7/2008	Vaccination with a recombinant Saccharomyces cerevisiae expressing a tumor antigen breaks immune tolerance and elicits therapeutic antitumor responses.
1/2008	Recombinant Saccharomyces cerevisiae (yeast-CEA) as a potent activator of murine dendritic cells.
10/2007	Generation of a prophylactic melanoma vaccine using whole recombinant yeast expressing MART-1.
2/2007	Whole recombinant yeast-based immunotherapy induces potent T cell responses targeting HCV NS3 and Core proteins.

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Alex Franzusoff Research Topics

Disease

14	Neoplasms (Cancer) 05/2016 - 09/2003
2	Glioma (Gliomas) 01/2007 - 09/2003
1	Prostatic Neoplasms (Prostate Cancer) 01/2014
1	Leukemia 08/2010
1	Carcinoma (Carcinomatosis) 02/2009
1	Neoplasm Metastasis (Metastasis) 07/2008
1	Communicable Diseases (Infectious Diseases) 01/2008
1	Melanoma (Melanoma, Malignant) 10/2007
1	Brain Neoplasms (Brain Tumor) 01/2007
1	Inflammation (Inflammations) 07/2004
1	Lung Injury 05/2002

Drug/Important Bio-Agent (IBA)

9	AntigensIBA 01/2016 - 07/2004
4	VaccinesIBA 08/2010 - 10/2007
3	Proteins (Proteins, Gene)FDA Link 10/2007 - 09/2003
2	Immune Checkpoint InhibitorsIBA 05/2016 - 01/2016
2	Neoplasm Antigens (Tumor Antigens)IBA 01/2016 - 01/2014
1	Antiviral Agents (Antivirals)IBA 05/2016
1	PROSTVACIBA 01/2014
1	Prostate-Specific Antigen (Semenogelase)IBA 01/2014
1	salicylhydroxamic acid (SHAM)IBA 08/2010
1	OvalbuminIBA 08/2010
1	CytokinesIBA 03/2010
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 03/2010
1	Carcinoembryonic AntigenIBA 02/2009
1	difluprednate FDA Link 10/2007
1	EpitopesIBA 10/2007
1	GI 5005IBA 02/2007
1	Cancer VaccinesIBA 01/2007
1	Transforming Growth Factor beta2IBA 01/2007
1	Messenger RNA (mRNA)IBA 01/2007
1	Antisense OligonucleotidesIBA 01/2007
1	Oncogene Proteins (Oncogene Protein)IBA 08/2004
1	CarcinogensIBA 08/2004
1	ras ProteinsIBA 08/2004
1	Fas Ligand Protein (Fas Ligand)IBA 07/2004
1	ErbB Receptors (EGF Receptor)IBA 09/2003
1	Silybin (Lagosa)IBA 09/2003
1	Superoxide DismutaseIBA 05/2002
1	AntioxidantsIBA 05/2002
1	EnzymesIBA 05/2002

Therapy/Procedure

9	Immunotherapy 01/2016 - 08/2004
1	Therapeutics 01/2016
1	Castration 01/2014